Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones

synthesis and cytotoxic evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents

Synthesis, antiviral and cytotoxic investigation of 2-phenyl-3-substituted quinazolin-4(3H)-ones.

OBJECTIVES A series of 3(benzylideneamino)-2-phenyl quinazoline-4(3H)-ones was synthesized by reaction of 3-amino-2-phenyl-3H-quinazoline-4-one with various carbonyl compounds. MATERIALS AND METHODS Chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR and mass spectral analysis. Title compounds were investigated for cytotoxicity and antiviral activity against herpes s...

SYNTHESIS OF 3-ARYLMETHYL-4- THIAZOLIDINE-CARBOXYLIC ACID-2-ONES AND 2-THIONES

Barium salts of dibenzylidene cystines 8a-c were obtained from the reaction of Lcystine with benzaldehyde or its derivatives in the presence of barium hydroxide. Their reduction with zinc and hydrochloric acid in methanol yielded the Narylmethylcysteines ?9a-c?. These can, in turn, be converted by esterification into the methyl esters ?10 a-c. ?Reaction of N, N'-carbonyl diimidazole (Im C...

synthesis and biological evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents

a series of 3-hydroxypyridin-4-one derivatives (hpos) were synthesized and their partition coefficient values (k part ) were determined. the cytotoxic effects of these iron chelators against hela cancer cells were also evaluated. the ic 50 of hpos was determined using mtt assay. among these ligands, compound 4e (k part =5.02) with an ic 50 of 30 µm and 4f (k part =0.1) with an ic 50 of 700 µm s...

Synthesis, In vitro Antimicrobial and Cytotoxic Activities of Some Novel Bis- 1, 3, 4-oxadiazoles

A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...